Prometryn

Prometryn is a triazine herbicide. Prometryn induces apoptosis and cell cycle arrest. Prometryn induces oxidative stress, DNA damage and autophagy-related gene expression, and non-specific immunity gene expression. Prometryn can be used for the research of herbicide, hepatopancreas injury, and intestinal stress and intestinal barrier dysfunction^[1][2][3][4]. In Vitro:Prometryn (25-200 μM; 24-48 h) decreases the viability of BEAS-2B cells in a time- and concentration-dependent manner^[1].
Prometryn (25-200 μM; 24-48 h) induces S phase cell cycle arrest in BEAS-2B cells at concentrations of 100 and 200 μM after 48 h of exposure, accompanied by reduced cyclin A and CDK2 expression and increased p53 expression^[1].
Prometryn (25-200 μM; 48 h) induces apoptosis in BEAS-2B cells in a concentration-dependent manner at 100 and 200 μM after 48 h of exposure, mediated by altered expression of Bcl2, Bax, Caspase 9, Caspase 3, and PARP^[1].
Prometryn (25-200 μM; 48 h) induces dose-dependent intracellular ROS generation in BEAS-2B cells, with significant increases detected at 200 μM after 48 h of exposure^[1].
Prometryn (25-200 μM; 48 h) induces dose-dependent DNA damage in BEAS-2B cells^[1].
Prometryn (5-20 mg/L; 96 hours) induces dose-dependent developmental toxicity in Danio rerio embryos over 96 hours, causing morphological defects, organogenesis failure, oxidative stress, apoptosis, and mitochondrial dysfunction, with an LC₅₀ value of 23.14 mg/L^[4].