MIRA-1
CAS No. : 72835-26-8
(Synonyms: NSC 19630)
| Size | Price | Stock |
|---|---|---|
| 1mg | $33 | In-stock |
| 5mg | $70 | In-stock |
| 10mg | $100 | In-stock |
| 25mg | $200 | In-stock |
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| Cat. No. : | HY-108639 |
| M.Wt: | 183.16 |
| Formula: | C8H9NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
MIRA-1 is a maleimide analogue. MIRA-1 can induce apoptosis in mutant p53 cells via restoration of p53-dependent transcriptional transactivation. MIRA-1 has anticancer activity[1].
IC50 & Target: IC50: 10 μM (Saos-2 His273)[1]
In Vitro: MIRA-1 suppresses growth of Saos-2-His273 cells expressing mutant p53[1].
MIRA-1 (25 μM; 48 hours) inhibits cell growth in a mutant p53-dependent manner[1].
MIRA-1 (5 μM; 14 days) dramatically reduces the number of colonies formed by His273-expressing Saos-2 cells, but is much less efficient in inhibiting p53-null Saos-2 cells[1].
MIRA-1 (10 μM; 48 hours) causes a substantial increase in the fraction of Saos-2 and Saos-2-His273 cells with a sub-G1 DNA content in the presence of mutant p53[1].
MIRA-1 (5 and 10 μM; 24 hours) induces EGFP expression, MDM2 and Bax in SKOV-His175 cells[1].
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