Deoxyartemisinin

Deoxyartemisinin (2-Deoxyartemisinin) is an orally active anti-inflammatory and analgesic agent. Deoxyartemisinin selectively reduces the level of the pro-inflammatory cytokine TNF-α. Deoxyartemisinin alleviates neuropathic pain, inflammatory pain, and croton oil-induced ear edema.\nDeoxyartemisinin exerts an analgesic effect against thermal stimulation. Deoxyartemisinin has anti-ulcer activity. Deoxyartemisinin can be used in research related to inflammatory diseases, pain, and gastric ulcers^[1][2]. In Vivo:Deoxyartemisinin (10-300 mg/kg; i.p.; single administration) reduces formaldehyde-induced neuropathic pain by 56.55% and inflammatory pain by 45.43% in male Swiss mice, exerts dose-dependent analgesic effects in the tail-flick test, and impairs spontaneous activity and motor coordination in male Swiss mice at the dose of 300 mg/kg^[1].
Deoxyartemisinin (100 mg/kg; i.p.; single administration) reduces croton oil-induced ear swelling by 33.64% and selectively decreases TNF-α levels by 37.37% in male Swiss mice^[1].
Deoxyartemisinin (50-200 mg/kg; p.o.; single administration) dose-dependently reduces the gastric ulcer injury index in ethanol-induced male Wistar rats, with an ED₅₀ of 87.5 mg/kg^[1].