Swainsonine
CAS No. : 72741-87-8
(Synonyms: Tridolgosir)
| Size | Price | Stock |
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| 1mg | $300 | In-stock |
| 5mg | $1180 | In-stock |
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| Cat. No. : | HY-N6722 |
| M.Wt: | 173.21 |
| Formula: | C8H15NO3 |
| Purity: | >98 % |
| Solubility: | Ethanol : 10 mg/mL (ultrasonic;warming) |
Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity[1][2][3].
In Vitro: Swainsonine (0-40 μM; 12 h) shows antiproliferative activity in U251 and LN444 cells[2].
Swainsonine (30 μM; 12 h) induces apoptosis and cell cycle arrest at G2/M phase, and decreases the expression of CyclinD1 and CDK4 protein levels, increases the expression of p16 protein level[2].
Swainsonine (30 μM; 12 h) reduces glioma cell migration and invasion[2].
In Vivo: Swainsonine (1 mg/kg; i.p.; twice daily for ten days) and cisplatin increases the anti-tumor efficacy in mouse[3].
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