2-(Bromomethyl)acrylic acid
CAS No. : 72707-66-5
(Synonyms: α-(Bromomethyl)acrylic acid; α-Methylated acrylamide; α-MAA)
| Size | Price | Stock |
|---|---|---|
| 250mg | $45 | In-stock |
| 1g | $84 | In-stock |
| 5g | $276 | In-stock |
| 10g | $450 | In-stock |
| 25g | $963 | In-stock |
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| Cat. No. : | HY-W017180 |
| M.Wt: | 164.99 |
| Formula: | C4H5BrO2 |
| Purity: | >98 % |
| Solubility: |
2-(Bromomethyl) acrylic acid is a Bruton's tyrosine kinase (BTK) inhibitor. 2-(Bromomethyl) acrylic acid forms a covalent bond with the cysteine 481 (Cys481) residue of BTK via a nucleophilic addition-elimination reaction, thereby inhibiting the downstream B-cell receptor signaling pathway. 2-(Bromomethyl) acrylic acid induces immunogenic cell death in BTK-expressing B-cell lymphoma cells by releasing damage-associated molecular patterns including extracellular ATP and HMGB1. 2-(Bromomethyl) acrylic acid exhibits cytotoxicity against BTK-expressing B-cell lymphoma cells, but shows low toxicity to BTK-negative cells. 2-(Bromomethyl) acrylic acid can be used in studies related to B-cell lymphoma[1]. In Vivo:Ibt-DOX (2.5 mg/kg; i.v.; once every 2 days; 14 days) reduces subcutaneous OCI-LY10 xenograft tumor volume by 54% in female SCID mice, with no significant weight loss or toxicity observed[1].
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