Ponalrestat
CAS No. : 72702-95-5
(Synonyms: ICI 128436)
| Size | Price | Stock |
|---|---|---|
| 5mg | $32 | In-stock |
| 10mg | $50 | In-stock |
| 25mg | $80 | In-stock |
| 50mg | $110 | In-stock |
| 100mg | $185 | In-stock |
| 250mg | $320 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-106697 |
| M.Wt: | 391.19 |
| Formula: | C17H12BrFN2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
Ponalrestat (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Ponalrestat selectively inhibits ALR2 (Ki=7.7 nM) over ALR1 (Ki=60 μM). Ponalrestat inhibits the conversion of glucose to sorbitol[1][2][3].
IC50 & Target: Ki: 7.7 nM (ALR2) and 60 μM (ALR1)[1]
In Vitro: Ponalrestat (ICI 128436; 1, 10, 100 μM; 6 hours) reduces PGF2αproduction in response to IL-1 in both cultured endometrial cells and endometrial explants[2].
In Vivo: Ponalrestat (ICI 128436; 10, 50 mg/kg; orally; daily; 8 weeks) reduces sorbitol accumulation indicating efficacy of aldose reductase inhibition[3].
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