γ-1-Melanocyte Stimulating Hormone (MSH), amide


CAS No. : 72629-65-3

72629-65-3
Price and Availability of CAS No. : 72629-65-3
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Cat. No. : HY-P1531
M.Wt: 1512.90
Formula: C72H97N21O14S
Purity: >98 %
Solubility: H2O : 25 mg/mL (ultrasonic)
Introduction of 72629-65-3 :

γ-1-Melanocyte Stimulating Hormone (MSH), amide is a 11-amino acid peptide. γ-1-Melanocyte Stimulating Hormone (MSH) regulates sodium (Na+) balance and blood pressure through activation of the melanocortin receptor 3 (MC3-R). IC50 & Target:Melanocortin receptor 3 (MC3-R)[1] In Vitro: γ-Melanocyte Stimulating Hormone (γ-MSH) regulates a multitude of metabolic functions including energy homeostasis, food intake, sodium (Na+) balance, and blood pressure regulation. γ-MSH is processed from the precursor hormone pro-opio-melanocortin (POMC) in the pituitary gland, where component peptides are released into the cerebral spinal fluid and systemic circulation. The natural receptor for γ-MSH is the melanocortin receptor 3 (MC3-R), a G-protein-coupled receptor that activates adenylate cyclase and is expressed in brain (hypothalamus, cortex, and thalamus), gut, placenta, and kidney. γ-MSH regulates Na+ balance by inducing urinary Na+ excretion (natriuresis) under conditions of high dietary salt intake[1].

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