Size | Price | Stock |
---|---|---|
5mg | $75 | In-stock |
10mg | $121 | In-stock |
50mg | $418 | In-stock |
100 mg | Get quote | |
200 mg | Get quote | |
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Cat. No. : | HY-10426 |
M.Wt: | 596.42 |
Formula: | C23H13F9N4O3S |
Purity: | >98 % |
Solubility: | DMSO : 16.67 mg/mL (27.95 mM; Need ultrasonic) |
XCT-790 is a potent and selective inverse agonist for ERRα with an IC50 value of 0.37 μM. XCT-790 induces cell death in chemotherapeutic resistant cancer cells. XCT-790 (Compound 12) is inactive against ERRγ and the estrogen receptors ERα and ERβ[1][2].
In Vitro: XCT-790 (0-40 μM; 48 hours and 72 hours) reduces the viability of MES-SA, MES-SA/DX5, and HepG2 cells in a dose-dependent manner[1].
XCT-790 (10 μM; 24 hours and 48 hours) reduces the protein levels of ERRα in HepG2 and R-HepG2 cell lines after 24 hours and maintains these reduced levels after 48 hours[1].
XCT-790 (10 μM; 48 hours) induces apoptosis in the two cell lines with HepG2 being more sensitive compared to R-HepG2[1].
In Vivo: XCT-790 (XCT790; 4 mg/kg; intravenous injection; every three days; for 3 weeks; BALB/c mice) significantly inhibits tumor growth and angiogenesis, and induces apoptosis without a reduction in body weight, in xenograft models[3].
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