Felodipine
CAS No. : 72509-76-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $121 | In-stock |
| 50mg | $164 | In-stock |
| 100mg | $222 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-B0309 |
| M.Wt: | 384.25 |
| Formula: | C18H19Cl2NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier[1][2][3].
In Vitro: Felodipine, a dihydropyridine calcium antagonist, is the most potent in relaxing porcine coronary arteries (IC50=0.15 nM)[1].
Felodipine, an L-type calcium channel blocker, induces autophagy and clears diverse aggregate-prone, neurodegenerative disease-associated proteins [2].
Felodipine blocks the muscarinic receptor-mediated (carbachol) Ca2+-dependent contraction of guinea pig ileum longitudinal smooth muscle (GPILSM) with an IC50 of 1.45 nM[3].
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