RRD-251
CAS No. : 72214-67-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $75 | In-stock |
| 25mg | $140 | In-stock |
| 50mg | $200 | In-stock |
| 100mg | $280 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-117737A |
| M.Wt: | 271.59 |
| Formula: | C8H9Cl3N2S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
RRD-251 is an inhibitor of retinoblastoma tumor suppressor protein (Rb)-Raf-1 interaction, with potent anti-proliferative, anti-angiogenic and anti-tumor activities[1].
IC50 & Target:Rb-Raf-1 interaction, apoptosis[1]
In Vitro: RRD-251 (10-50 μM; 24 hours) inhibits melanoma growth in-vitro[1].
RRD-251 (50 μM; 2 hours) inhibits Rb-Raf-1 interaction and Rb phosphorylation in non-small cell lung cancer cells[1].
RRD-251 induces apoptosis (50 μM; 18 hours) and cell cycle arrest (20-50 μM; 4 hours)[1].
RRD-251 alters the expression of cell cycle and apoptosis regulatory protein[1].
In Vivo: RRD-251 (50 mg/kg; i.p.; q.o.d; for 14 days) has anti-cancer activities in vivo on melanomas[1].
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