Chlorquinaldol


CAS No. : 72-80-0

(Synonyms: Chloquinan)

72-80-0
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Cat. No. : HY-B1360
M.Wt: 228.08
Formula: C10H7Cl2NO
Purity: >98 %
Solubility: DMSO : 50 mg/mL (ultrasonic)
Introduction of 72-80-0 :

Chlorquinaldol (Chloquinan) is an antibacterial agent with the potential use in topical skin conditions and vaginal infections. Chlorquinaldol is a β-catenin/TCF4 inhibitor, showing anti-proliferation, anti-migration, and apoptosis-inducing activity in cancer cells. In Vitro:Chlorquinaldol (Chloquinan; 5, 10 μM; 24 h) inhibits Wnt/β-catenin signaling by disrupting β-catenin/TCF4 complex in colorectal cancer (CRC) cell[2].
Chlorquinaldol (5, 10 μM; 24 h) inhibits β-catenin acetylation in CRC cells, thereby reducing the interaction of β-catenin with TCF4[2].
Chlorquinaldol (0.5, 1, 2 μM; 24 h) inhibits the stemness of CRC cells and exerts anti-CRC activity in vitro and in vivo[2].

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