Nortriptyline
CAS No. : 72-69-5
(Synonyms: Desmethylamitriptyline; Desitriptilina)
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| 1g | $280 | In-stock |
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| Cat. No. : | HY-118620 |
| M.Wt: | 263.38 |
| Formula: | C19H21N |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects[1][2][3].
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In Vitro:Amitriptyline is metabolized by CYP2C19 to the active metabolite, Nortriptyline. Nortriptyline blocks the reuptake of Norepinephrine more potently than Serotonin[1].
Nortriptyline (6.25-100 μM; 24-72 h) markedly reducs the viability of TCCSUP and mouse MBT-2 bladder cancer cells in a concentration- and time-dependent manner[3].
Nortriptyline (12.55-100 μM; 24 h) induces cell cycle arrest and apoptosis in TCCSUP and MBT-2 cells[3].
Nortriptyline (12.55-100 μM; 24 h) induces both intrinsic and extrinsic apoptosis in these bladder cancer cells[3].
In Vivo:Nortriptyline (10-20 mg/kg; ip; every day; for three weeks) inhibits the growth of bladder tumors in mice inoculated with MBT-2 cells[3].
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