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Artemether


CAS No. : 71963-77-4

(Synonyms: Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224)

71963-77-4
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Cat. No. : HY-N0402
M.Wt: 298.37
Formula: C16H26O5
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic);H2O : < 0.1 mg/mL
Introduction of 71963-77-4 :

Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria[1]. In Vitro: Artemether (0-200 μg/mL, 24-72 h) inhibits rat C6 glioma cell growth in a dose- and time-dependent manner[2].
Artemether (0-10 μM, 72 h) inhibits RANKL-induced osteoclast (osteoclast precursor cells (BMMs)) formation and related gene expression (TRAP, NFATc1, V-ATPase-d2, CTSK, DC-STAMP, MMP-9)[2].
Artemether (48 or 96 h) inhibits ConA- or alloantigen-induced BALB/c splenocyte proliferation (IC50: 6.3 and 3.5 μM)[4].
Artemether (0-50 μM, 16-36 h) inhibits production of the IL-2 and IFN-γ in BALB/c splenocyte[4].
Artemether (0-50 μM, 72 h) inhibits ConA-induced splenocyte, CD4+T- and CD8+ T-cell divisions, and inhibits cell cycle progression through G1/S transition[4].
In Vivo: Artemether (0-66 mg/kg, p.o.) inhibits tumor growth and angiogenesis in SD rats bearing C6 glioma cells[2].
Artemether (10 mg/kg, i.p., 8 days) protects mice against LPS-induced osteolytic bone loss[3].
Artemether (50 and 100 mg/kg, p.o.) inhibits T-cell-mediated immune responses (ear swelling) in DNFB-induced DTH model in BALB/c mice[4].

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