Aβ aggregation modulator-1

Aβ aggregation modulator-1 is a stimulator of amyloid-β (Aβ) fibrillogenesis. Aβ aggregation modulator-1 binds hydrophobic residues in Aβ peptides and stabilizes β-sheet-rich protofibrils and fibrils. Aβ aggregation modulator-1 accelerates Aβ polymerization and reduces concentrations of small, toxic Aβ oligomers in heterogeneous aggregation reactions. Aβ aggregation modulator-1 suppresses long-term potentiation (LTP) inhibition by Aβ oligomers in hippocampal brain slices. Aβ aggregation modulator-1 can be used for the study of Alzheimer's disease (AD)^[1]. In Vitro:Aβ42-IN-6 (Compound O4) (48 h) reduces Aβ₄₂-induced toxicity in differentiated SH-SY5Y cells and primary cortical neurons^[1].
Aβ42-IN-6 (5-25 μM; 48 h) promotes aggregation of Aβ₄₂ in SH-SY5Y cell culture media, decreasing the abundance of soluble Aβ₄₂ monomers and small oligomers while increasing larger aggregate structures^[1].
Aβ42-IN-6 (5 μM, 48 h) stimulates the formation of SDS-resistant Aβ aggregates in 7PA2 cells (CHO cells overexpressing mutant human APP)^[1].
Aβ42-IN-6 suppresses Aβ₄₂- induced inhibition of hippocampal long-term potentiation (LTP) in the CA1 area of rat brain slices, rescuing the dysfunction of synaptic plasticity caused by toxic Aβ₄₂ oligomers^[1].