| Size | Price | Stock |
|---|---|---|
| 500μg | $200 | Get quote |
| 1mg | $340 | In-stock |
| 5mg | $612 | In-stock |
| 10mg | $856 | In-stock |
| 25mg | $1712 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
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| Cat. No. : | HY-N6742 |
| M.Wt: | 489.64 |
| Formula: | C28H43NO6 |
| Purity: | >98 % |
| Solubility: | Ethanol : ≥ 100 mg/mL |
Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor which is a nitrile-containing macrolide antibiotic isolated from Streptomyces rochei[1]. Borrelidin is an inhibitor of Cdc28/Cln2 of the budding yeast, with an IC50 of 24 μM[2]. Borrelidin is a potent angiogenesis inhibitor, with an IC50 of 0.8 nM. Borrelidin induces apoptosis in the tube-forming cells[3]. Borrelidin has strong antimalarial activities, with IC50s of 1.9 nM and 1.8 nM against K1 and FCR3 strains of Plasmodium falciparum, respectively[4].
IC50 & Target: IC50:24 μM (Cdc28/Cln2)[2]
In Vitro: Borrelidin can target ALL cell lines and induce apoptosis and mediating G1 arrest[1].
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