Monactin
CAS No. : 7182-54-9
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| Cat. No. : | HY-111525 |
| M.Wt: | 750.96 |
| Formula: | C41H66O12 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity[1][2][3].
In Vitro: Monactin displays strong antiproliferative activity against A2780 ovarian cancer cells (IC50 0.13 μM), A2058 melanoma cells (0.02 μM), and H522-T1 non small-cell cancer lung cells (0.01 μM)[3].
Monactin inhibits TCF/β-catenin transcriptional activity[4].
At a concentration of 10 μM, nigericin and monactin inhibited growth of Streptococcus faecalis, and the inhibition was reversed by addition of excess K(+)[5].
In Vivo: Monactin is potent uncoupler of oxidative phosphorylation and inducer of ATP hydrolysis in rat liver mitochondria[1].
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