PF-431396
CAS No. : 717906-29-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $67 | In-stock |
| 10mg | $108 | In-stock |
| 25mg | $204 | In-stock |
| 50mg | $336 | In-stock |
| 100mg | $540 | In-stock |
| 200mg | $990 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-10460 |
| M.Wt: | 506.50 |
| Formula: | C22H21F3N6O3S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
PF-431396 is an orally active dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor, with IC50 values of 2 nM and 11 nM, respectively[1][2][3][4].
IC50 & Target:IC50: 2 nM (FAK); 11 nM (PYK2)[1].
Kd: 445 nM (BRD4)[1].
In Vitro: PF-431396 has a Kd value of 445 nM for BRD4[2].
PF-431396 appeares to selectively inhibit BCR-induced tyrosine phosphorylation of Pyk2 and FAK[3].
PF-431396 (2.5, 5 μM, 45 min) inhibits the phosphorylation of Pyk2 and FAK induced by clustering LFA-1 with plate-bound Abs[3].
In Vivo: PF-431396 (10 or 30 mg/kg, orally) prevents bone loss induced by estrogen deficiency in rats primarily by stimulating bone formation, providing independent pharmacological confirmation for the function of PYK2 in regulating bone formation[4].
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