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| Cat. No. : | HY-114707 |
| M.Wt: | 334.37 |
| Formula: | C13H26N4O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Threonyl-seryl-lysine, a bovine pineal antireproductive tripeptide, has antigonadotropic activity. Threonyl-seryl-lysine binds to luteinizing hormone-releasing hormone (LHRH) at a site comprised of LHRH 2-5[1][3].
In Vivo:Threonyl-seryl-lysine (175 ng, i.p.) reduces the 5-day compensatory ovarian hypertrophy in unilaterally ovariectomized (UO) mice[1].
Threonyl-seryl-lysine (1 or 5 μg, i.p.) delays vaginal opening time in female Charles River CD rats[2].
Threonyl-seryl-lysine (1 and 10 μg, s.c., for 15 days) increases the weight of ovaries and of adrenals in mice[4].
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