Ilimaquinone

Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Ilimaquinone can induce vesiculation of the Golgi apparatus^[1]. Ilimaquinone exerts anti-HIV, anti-microbial, anti-inflammatory, and effects^[2]. In Vitro: Ilimaquinone induces a concentration-dependent anti-proliferative effect in several types of cancer cell lines, including prostate cancer PC-3 and LNCaP, non-small cell lung cancer A549 and hepatocellular carcinoma Hep3B cells. Ilimaquinone (0.3-30 μM ; 48 hours) inhibits the proliferation of PC-3 cells, DU145, LNCaP, MG63, A549, Hep3B cells with GI₅₀s of 2.6 μM, 5.8, 4.6, 4.9, 4.1, 12.0μM, respectively^[1]. In Vivo: Ilimaquinone exhibits terminal elimination half-lives (T_1/2=1.2±0.3 h) due to high plasma clearance (2.95±0.53 L/h/kg) following oral administration (10 mg/kg) in male Sprague-Dawley rats^[2].