Naphthalene-2,3-dicarboxaldehyde
CAS No. : 7149-49-7
(Synonyms: 2,3-Naphthalenedicarboxaldehyde; Naphthalene-2,3-dialdehyde)
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| Cat. No. : | HY-W016288 |
| M.Wt: | 184.19 |
| Formula: | C12H8O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C) |
Naphthalene-2,3-dicarboxaldehyde (NDA) is an effective inhibitor of Candida albicans aspartate semialdehyde dehydrogenase (ASADH), with a Ki value of 45 μM. Naphthalene-2,3-dicarboxaldehyde targets ASADH in the aspartate biosynthetic pathway of Candida albicans. Naphthalene-2,3-dicarboxaldehyde reacts with primary amines to generate highly fluorescent and stable derivatives. Naphthalene-2,3-dicarboxaldehyde serves as a fungistatic agent and a fluorogenic derivatization reagent. Naphthalene-2,3-Dicarboxaldehyde can be used for the research of candidiasis[1][2][3].
In Vitro:Naphthalene-2,3-dicarboxaldehyde (2 mM; serial dilutions) inhibits purified Candida albicans aspartate semialdehyde dehydrogenase with a Ki of 45 μM[1].
Naphthalene-2,3-dicarboxaldehyde inhibits growth of Candida albicans CAF2-1 with an MIC of 12 μg/mL and an IC50 of 58.2 μM[1].
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