APETx2
CAS No. : 713544-47-9
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| Cat. No. : | HY-P1346 |
| M.Wt: | 4561.00 |
| Formula: | C196H280N54O61S6 |
| Purity: | >98 % |
| Solubility: | H2O |
APETx2, a sea anemone peptide from Anthopleura elegantissima, is a selective and reversible ASIC3 inhibitor, with an IC50 of 63 nM. APETx2 directly inhibits the ASIC3 channel by acting at its external side. APETx2 could reverses acid‐induced and inflammatory pain[1][2]. In Vitro: APETx2 (i.t. or i.m. application, 0.022 to 2.2 µM) resulted in a potent and complete reversal of established mechanical hypersensitivity in the complete Freund's adjuvant (CFA) inflammatory pain model[2].
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