Fenoxaprop-P-ethyl

Fenoxaprop-P-ethyl is an acetyl-CoA carboxylase (ACC) inhibitor and post-emergence herbicide. Fenoxaprop-P-ethyl inhibits the conversion of acetyl-CoA to malonyl-CoA, reduces malonyl-CoA synthesis and disrupts fatty acid synthesis. Fenoxaprop-P-ethyl disrupts lipid homeostasis through cascaded inhibition of lipid metabolism, decreases total lipid content, downregulates fatty acid elongase genes and inhibits their activity. Fenoxaprop-P-ethyl disrupts fatty acid synthesis in rice seedlings and controls annual monocotyledonous weeds in wheat, durum wheat, rye, triticale and barley fields^[1][2]. In Vitro:Fenoxaprop-P-ethyl (0.4 mg/L; 1 h immersion) downregulates genes encoding fatty acid elongation enzymes (KCS, KCR, HCD, ECR) in rice (Oryza sativa variety 9311) seedling stem and leaf tissue 2 days post-treatment, and time-dependently inhibits their activities^[1].
Fenoxaprop-P-ethyl produces positive results in the in vitro chromosome aberration assay in human lymphocytes^[2]. In Vivo:Fenoxaprop-P-ethyl poses a low risk to healthy birds and wild mammals across all representative uses^[2].
Fenoxaprop-P-ethyl (92.1 mL/ha) poses a low risk to most healthy invertebrate organisms, except for a high in-field risk to non-target arthropods when using the CHA 4960 formulation^[2].
Fenoxaprop-P-ethyl and most of its metabolites pose a low risk to healthy aquatic organisms, but a high risk is identified in specific FOCUS surface water scenarios for fenoxaprop-P, fenoxaprop-M, and phenol metabolite^[2].