PNU-282987 (free base)
CAS No. : 711085-63-1
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| Cat. No. : | HY-12560 |
| M.Wt: | 264.75 |
| Formula: | C14H17ClN2O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
PNU-282987 (free base) is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 (free base) is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 (free base) can be used for the research of central and peripheral nervous systems[1].
IC50 & Target:IC50: 4541nM (5-HT3); EC50: 154 nM (α7 nAChR); Ki: 27 nM (R7 MLA)[1]
In Vitro:PNU-282987 (free base) (Compound C7) displaces the R7 selective antagonist methyllycaconitine (MLA) from rat brain homogenates with a Ki of 27 nM[1].
PNU-282987 has α7 nAChR agonist activity with an EC50 of 154 nM[1].
PNU-282987 also has inhibition for the 5-HT3 receptor with an IC50 value of 4541nM[1].
In Vivo:PNU-282987 (free base) (Compound C7) (i.v.; 1, 3 mg/kg) leads to a reversal of the gating deficit[1].
PNU-282987 (30 μM) evokes currents in rat hippocampal neurons in a concentration-dependent and MLA blockable manner[1].
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