PIK-124
CAS No. : 711025-68-2
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| Cat. No. : | HY-118903 |
| M.Wt: | 434.88 |
| Formula: | C19H12ClFN2O3S2 |
| Purity: | >98 % |
| Solubility: |
PIK-124 is a thiazolidinone-based PI3Kγ-biased PI3K inhibitor, with an IC50 of 3 nM against PI3Kγ. PIK-124 exhibits cross-reactivity with PI3Kα (IC50 = 23 nM), PI3Kδ (IC50 = 340 nM), PI3KC2α (IC50 = 140 nM) and PI3KC2β (IC50 = 370 nM). PIK-124 is applicable to breast cancer-related research[1][2]. In Vitro:PIK-124 shows weak inhibitory effect on p-Akt in PTEN-WT cells, but effectively inhibits PI3Kγ-enriched systems[2].
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