MRS 2578
CAS No. : 711019-86-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $48 | In-stock |
| 10mg | $77 | In-stock |
| 25mg | $145 | In-stock |
| 50mg | $231 | In-stock |
| 100mg | $370 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-13104 |
| M.Wt: | 472.67 |
| Formula: | C20H20N6S4 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
MRS 2578 is a selective and potent P2Y6 receptor antagonist with IC50s of 37 nM (human) and 98 nM (rat). MRS 2578 exhibits insignificant activity at P2Y1, P2Y2, P2Y4, and P2Y11 receptors[1][2].
IC50 & Target: IC50: 37 nM (human P2Y6 receptor), 98 nM (rat P2Y6 receptor)[2]
In Vitro: MRS2578 (1 μM) completely blocks the protection by UDP undergoing TNFα-induced apoptosis in 1321N1 astrocytoma cells[1].
MRS 2578 (10 μM) completely abolishes TNF-α induced NF-κB reporter activity in HMEC-1 cells. MRS 2578 (10 μM) significant reduces TNF-α–induced proinflammatory gene expression in HMEC-1 cells[2].
In Vivo: MRS2578 (3 mg/kg; i.p.; for 3 days) significantly suppresses pressure overload-induced collagen deposition without affecting cardiomyocyte hypertrophy after transverse aortic constriction (TAC)[4].
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