Digitoxin
CAS No. : 71-63-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $25 | In-stock |
| 10mg | $33 | In-stock |
| 25mg | $55 | In-stock |
| 50mg | $74 | In-stock |
| 100mg | $110 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-B1357 |
| M.Wt: | 764.94 |
| Formula: | C41H64O13 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Digitoxin is an anti-cancer agent. Digitoxin induces apoptosis, inhibits influenza cytokine storm, causes DNA double-stranded breaks (DSBs) and blocks the cell cycle at the G2/M phase. Digitoxin induces calcium uptake into cells by forming transmembrane calcium channels and can be used for research of heart failure [1][2][3][4][5].
In Vitro:Digitoxin (0-80 nM, 72 h) compromised cell survival in PC12 cells[1].
Digitoxin (4-1000 nM, 24-48 h) has an antitumor effects in MHCC97H, A549, HCT116 and HeLa cells[3].
Digitoxin (4-100 nM, 24-48 h) disrupts the cell cycle in HeLa cells[3].
Digitoxin (20-500 nM, 48 h) activates mitochondrial apoptosis in HeLa cells[3].
In Vivo:Digitoxin (1-2 mg/kg, Intraperitoneal injection, once a day for 19 days) has anticancer effects in nude mice[3].
Digitoxin (0.3-3 μg/kg, Intraperitoneal injection, once a day for 4 days) blocks the host over-production of cytokines in the cotton rat lung[4].
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