Medroxyprogesterone acetate
CAS No. : 71-58-9
(Synonyms: Medroxyprogesterone 17-acetate; Farlutin)
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|---|---|---|
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| 5g | $285 | In-stock |
| 10g | $456 | In-stock |
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| Cat. No. : | HY-B0469 |
| M.Wt: | 386.52 |
| Formula: | C24H34O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic);H2O : < 0.1 mg/mL;Ethanol : 6.25 mg/mL (ultrasonic;warming;heat to 60°C) |
Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors[1].
In Vitro:Medroxyprogesterone acetate (10 and 0.5 nM, 48 h) inhibits Steroid-deprived HUVEC eNOS expression[2].
Medroxyprogesterone acetate (10 and 0.5 nM, 16 h) inhibits leukocyte adhesion to human endothelial cells (Steroid-deprived HUVECs) by reduing endothelial adhesion molecule (VCAM-1 and ICAM-1 protein) expression[2].
Medroxyprogesterone acetate (10 and 0.5 nM, 2 h) reduces NF-κB nuclear translocation in Steroid-deprived HUVECs[2].
In Vivo:Medroxyprogesterone acetate (5 mg/kg, oral gavage, rats) shows a Cmax of 377.9 ng/mL, AUC0- 2535.9 ng·h/mL, t1/2 of 10.2 h[3].
Medroxyprogesterone acetate (0.05-0.2 mg/kg/day, p.o., 14 days, rats) increases allopregnanolone levels in all tissues except in the adrenal gland, and affects β-END levels in the hippocampus[4].
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