15(S)-HPETE
CAS No. : 70981-96-3
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| Cat. No. : | HY-113438 |
| M.Wt: | 336.47 |
| Formula: | C20H32O4 |
| Purity: | >98 % |
| Solubility: |
15(S)-HPETE is a precursor of 15(S)-HETE (HY-113336). 15(S)-HPETE is a product of Arachidonic acid (HY-109590) in the 15-lipoxygenase pathway. 15(S)-HPETE reduces Bcl-2, Akt, and phosphorylated Akt protein levels. 15(S)-HPETE induces Apoptosis. 15(S)-HPETE antagonizes the angiogenic effects of 15(S)-HETE. 15(S)-HPETE exhibits antitumor effects against chronic myeloid leukemia. 15(S)-HPETE can be used in adipose tissue explant studies[1][2][3].
In Vitro:15(S)-HPETE (0.1 μM; 24 h) reverses the pro-angiogenic effect of 15(S)-HETE in HUVECs, with reducing CD31 and VEGF production[1].
15(S)-HPETE (0.1 μM) significantly inhibits endothelial cell sprouting from rat epididymal adipose tissue explants[2].
15(S)-HPETE (1-20 μM; 3-24 h) inhibits the viability of K-562 cells (chronic myeloid leukemia cells) and induced their apoptosis[3].
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