MMRi6
CAS No. : 709009-15-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $103 | In-stock |
| 10mg | $166 | In-stock |
| 25mg | $332 | In-stock |
| 50mg | $530 | In-stock |
| 100mg | $850 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-124791 |
| M.Wt: | 396.27 |
| Formula: | C21H15Cl2N3O |
| Purity: | >98 % |
| Solubility: |
MMRi6 is a Mdm2-MdmX RING domain inhibitor that can disrupt Mdm2-MdmX RING-RING interaction in vitro. MMRi6 inhibits MdmX-stimulated Mdm2 autoubiquitination and Mdm2-MdmX-mediated p53 polyubiquitination in vitro without affecting NEDD4-1 autoubiquitination. MMRi6 induces p53 stabilization and accumulation and induces PARP cleavage in wt-p53 Emu-myc lymphoma cells. MMRi6 inhibits the growth of wt-p53 and p53-null Emu-myc lymphoma cells with IC50s of approximately 0.5 μM and 3 μM, respectively. MMRi6 can be used for the study of leukemia/lymphoma[1].
In Vitro:MMRi6 (10 μM) inhibits Mdm2 autoubiquitination and p53 ubiquitination by Mdm2–MdmX in vitro[1].
MMRi6 (5 μM, 8 h) induces p53 protein accumulation in HCT-8 cells and in wt-p53 Emu-myc lymphoma cells[1].
MMRi6 (0.5 μM, 24 h) induces PARP cleavage in wt-p53 Emu-myc lymphoma cells but not in p53-null Emu-myc lymphoma cells[1].
MMRi6 (0.5-1 μM, 72 h) inhibits the growth of wt-p53 and p53-null Emu-myc lymphoma cells with IC50s of approximately 0.5 μM and 3 μM, respectively[1].
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