L-Chicoric Acid
CAS No. : 70831-56-0
(Synonyms: (-)-Chicoric acid; trans-Caffeoyltartaric acid)
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| Cat. No. : | HY-N0457A |
| M.Wt: | 474.37 |
| Formula: | C22H18O12 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 3.33 mg/mL (ultrasonic;warming;heat to 60°C) |
L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC50 of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture[1][2][3].
IC50 & Target:IC50: ~100 nM (HIV-1 integrase)[1][2]
HIV-1[2]
In Vitro:L-Chicoric Acid inhibits integration at concentrations from 500 nM to 10 μM but also inhibits entry at concentrations above 1 μM. L-Chicoric Acid clearly affects viral entry at concentrations of 5 μM and higher. L-Chicoric Acid also inhibits integration as indicated both by an increased ratio of two LTR circle DNA to cDNA and an accompanying decrease in integrated provirus. The EC50 of L-Chicoric Acid against HIV is approximately 500 nM, a concentration that does not inhibit HIV entry in H9 cells[1].
The ED50 of L-Chicoric Acid against HIVNL4-3 control virus is 400 nM, while HIVNL4-3 passaged in the presence of 8 μM L-Chicoric Acid is completely resistant to the compound[2].
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