CFL-137
CAS No. : 708-06-5
| Size | Price | Stock |
|---|---|---|
| 25g | $9 | In-stock |
| 50g | $17 | In-stock |
| 100g | $31 | In-stock |
| 500g | $138 | In-stock |
| 1000g | $269 | In-stock |
| > 2 kg | Get quote | |
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| Cat. No. : | HY-W016889 |
| M.Wt: | 172.18 |
| Formula: | C11H8O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
CFL-137 is a potent KRasG12C inhibitor. CFL-137 shows an antiproliferative effect. CFL-137 shows anticancer activity. CFL-137 has the potential for the research of lung cancer[1].
In Vitro:CFL-137 (72 h) shows an antiproliferative effect with IC50s of 11.4, 24.2, 24.5, 12.3, 43.3, 44.5, 27.63, 32.4, 46.9, 26.2, 25.0, 10.8, 66.2 µM for H1792, SW1573, MiaPaca2, H358, A549, SW480, PANC-1, LCLC-103H, BxPC3, HCA-7, MRC-5, HUVEC-TERT, CCD-986Sk cells, respectively[1].
In Vivo:CFL-137 (5 mg/kg, 5 treatments; 15 mg/kg, 5 treatments; 30 mg/kg, 3 treatments; i.p.) reduces tumor growth in subcutaneous H1792 (KRasG12C mutant) and LCLC-103H (KRasWT) human lung cancer-bearing mice[1].
Pharmacokinetic Parameters of CFL-137 in NOD-SCID female mice[1].
| PK parameters | CFL-137 |
| Cmax (ng/mL) | 27,366 ± 13,221 |
| Tmax (h) | 0.25 |
| AUCt (ng/mL*h) | 28,307 ± 6375 |
| t1/2 (h) | 4.0 ± 0.2 |
| Vd (mL) | 63.6 ± 13.6 |
| CL(mL/h) | 11.0 ± 2.8 |
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