Cefpiramide
CAS No. : 70797-11-4
(Synonyms: SM-1652 (free acid); Wy-44635 (free acid))
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| 10mg | $144 | In-stock |
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| Cat. No. : | HY-B1354 |
| M.Wt: | 612.64 |
| Formula: | C25H24N8O7S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Cefpiramide (SM-1652) free acid is a semisynthetic cephalosporin with broad-spectrum antibacterial activity. Cefpiramide free acid shows strong antibacterial effect on both gram-positive bacteria and gram-negative bacteria. Cefpiramide free acid is moderately susceptible to β-lactamase[1][2].
IC50 & Target: Bacterial[1][2]
In Vitro: Cefpiramide (0-2048 µg/mL; 16-18 hours) shows good activity to against most non-fermentative Gram-negative bacilli and Enterococci (32 µg/mL with 97% inhibition)[1].
Cefpiramide (0-2048 µg/mL; 16-18 hours) exhibits high effective to against Pseudomonas aeruginosa with MIC[50] and MIC[90] values of 4 µg/mL and 16 µg/mL separately[1].
In Vivo: Cefpiramide (25 mg/kg; i.v.; once) shows anti-Streptococcus pneumoniae activity in experimental pneumococcal meningitis[2].
Cefpiramide (25 mg/kg; i.v.; once) reduces bacteria in CSF more than 10[4] CFU/ml[2].
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