Flurofamide

Flurofamide is an effective bacterial urease inhibitor and antibacterial agent. Flurofamide inhibits urease and partially inhibits the chemotactic activity of Helicobacter pylori strain CPY3401. Flurofamide inhibits the growth of Ureaplasma urealyticum. Flurofamide reduces blood ammonia. Flurofamide can be used in the research of infectious urinary stones^[1][2][3][4]. In Vitro:Flufatamide inhibits NH₃ production in 4 isolates of Ureaplasma parvum and 5 isolates of Ureaplasma urealyticum, with the minimum urease inhibition concentration ≤ 2 μM, confirming that it is a broad-spectrum Ureaplasma urease inhibitor^[1].
Flurofamide (0.01-10 μM) partially inhibits the chemotactic activity of Helicobacter pylori CPY3401 strain in chemotactic buffer containing 3% Polyvinylpyrrolidone (simulating a viscous environment)^[2]. In Vivo:Flurofamide (6 mg/kg; i.p., 1 h before infection in the prophylaxis group and 24 h after infection in the treatment group) significantly reduces blood ammonia levels in the prophylaxis group 24 hours later, and makes the reduction of blood ammonia levels in the treatment group 6 h later significantly greater than that in the untreated group in the Ureaplasma respiratory infection model of immunosuppressed C3H mice with induced mild uremia^[1].