2-Deoxy-2-fluoro-L-fucose
CAS No. : 70763-62-1
| Size | Price | Stock |
|---|---|---|
| 100mg | $150 | In-stock |
| 250mg | $260 | In-stock |
| 1g | $551 | In-stock |
| 5g | $1571 | In-stock |
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| Cat. No. : | HY-116705 |
| M.Wt: | 166.15 |
| Formula: | C6H11FO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
2-Deoxy-2-fluoro-L-fucose, an L-fucose analog, is a fucosylation inhibitor. 2-Deoxy-2-fluoro-L-fucose inhibits de novo synthesis of GDP-fucose in mammalian cells. Fucosylation is a relatively well-defined biomarker for progression in many human cancers; for example, pancreatic and hepatocellular carcinoma[1].
In Vitro: 2-Deoxy-2-fluoro-L-fucose (2FF) (100-500 μM)) suppresses fucosylation in 4T1 cells[1].
2-Deoxy-2-fluoro-L-fucose (100 μM; 4T1 cells) decreases phosphorylation of Smad 1/5 and Smad 2[1].
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