Aligeron
CAS No. : 70713-45-0
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| Cat. No. : | HY-101602 |
| M.Wt: | 292.42 |
| Formula: | C20H24N2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Aligeron is a non-selective prostaglandin (PG) antagonist, and has vasodilatory properties. In Vitro:Aligeron shows a broad spectrum of antagonistic action against different spasmogens in different isolated organs. The experiments on isolated perfused rabbit artery shows the antagonistic action of aligeron against the vasoconstrictor effects of noradrenaline and adrenaline[1]. In Vivo:In hypoventilation hypoxia, aligeron (5 mg/kg i.v.) and cinnarizine increase cortical resistance to hypoxia and accelerated the recovery of cortical bioelectrical activity. In KCl- and AMP-induced depressions aligeron shows a protective effect manifested in a decrease of the degree and duration of the depression[2].
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