NS3763
CAS No. : 70553-45-6
| Size | Price | Stock |
|---|---|---|
| 500μg | $540 | Get quote |
| 1mg | $940 | Get quote |
| 2.5mg | $1892 | Get quote |
| 5mg | $3362 | Get quote |
| 10 mg | Get quote | |
| 50 mg | Get quote | |
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| Cat. No. : | HY-107603 |
| M.Wt: | 404.37 |
| Formula: | C22H16N2O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
NS3763 is a selective and noncompetitive GLUK5 receptor antagonist with an IC50 of 1.6 µM. NS3763 does not show significant antagonistic properties on GLUK6, AMPA or NMDA receptors[1].
IC50 & Target: IC50: 1.6 µM (GLUK5 receptor)[1]
In Vitro: In human embryonic kidney HEK293 cells expressing homomeric GLUK5 or GLUK6 receptors, NS3763 displays selectivity for inhibition of domoate-induced increase in intracellular calcium mediated through the GLUK5 subtype (IC50 = 1.6 µM) of kainate receptors compared with the GLUK6 subtype (IC50 > 30 µM)[1].
NS3763 selectively inhibits l-glutamate- and domoate-evoked currents through GLUK5 receptors in HEK293 cells[1].
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