2′-Hydroxy-5′-methoxyacetophenone

2'-Hydroxy-5'-methoxyacetophenone is an acetophenone derivative with acaricidal activities. 2'-Hydroxy-5'-methoxyacetophenone attenuates the inflammatory response via NF-κB signaling pathway. 2'-Hydroxy-5'-methoxyacetophenone exhibits significant inhibitory activity against α-amylase, collagenase and aldose reductase (AR) with IC₅₀s of 0.928, 3.264 and 20.046 μM, highlighting its potential in combating diabetes. 2'-Hydroxy-5'-methoxyacetophenone exhibits anti-ovarian cancer activity^[1][2][3]. In Vitro: 2'-Hydroxy-5'-methoxyacetophenone (10-200 μM, 24 h) exhibits anti-ovarian cancer activity against PA-1, Caov-3, and SK-OV-3 cell lines with IC₅₀s of 271, 326 and 405 µg/mL, respectively and has no cytotoxicity on has no cytotoxicity on BV-2 and RAW264.7 cells^[1].
2'-Hydroxy-5'-methoxyacetophenone (10-200 μM, 19-25 h) significantly decreases the LPS (HY-D1056)-induced NO, TNF-α, ROS, iNOS and COX-2 production and inhibits NF-κB signaling pathway in BV-2 and RAW264.7 cells^[1].
2'-Hydroxy-5'-methoxyacetophenone exhibits LD₅₀ values against D. farina, D. pteronyssinus and T. putrescentiae of 1.03, 1.13 and 1.78 μg/cm².