Teleocidin A1

Teleocidin A1 (Lyngbyatoxin A) is a PKC activator with a K_i value of 0.11 nM for binding to the PKCδ-C1B peptide. Teleocidin A1 exhibits anticancer activity against cervical cancer and leukemia. Teleocidin A1 can induce seaweed dermatitis, food poisoning and local skin toxicity. Teleocidin A1 can be used in studies related to cervical cancer, seaweed dermatitis and food poisoning^[1][2][3][4]. In Vitro:Teleocidin A1 (incubated for 48 h) potently inhibits the proliferation of HeLa cervical cancer cells, with an IC₅₀ value of 9.2 nM^[1].
Teleocidin A1 (incubated for 24 h) inhibits the proliferation of L1210 mouse leukemia cells, with an IC₅₀ value of 8.1 μM^[2].
Teleocidin A1 binds to the PKCδ-C1B peptide segment with high affinity, with a K_i value of 0.11 nM for the inhibition of [³H]PDBu, a result that confirms the aforementioned binding characteristics^[2].
Lyngbyatoxin A (26 μg/cm²; 1-48 h) rapidly penetrates the abdominal skin of ex vivo male Hartley guinea pigs, reaching a peak of 23% of the administered dose within 1 hour, with no significant changes in the penetration amount at subsequent time points^[3]. In Vivo:Teleocidin A1 (administered via injection) exhibits potent lethal activity against Palaemon paucidens (slender prawn), with an LD₃₃ value of 0.6 mg/kg, which is significantly higher than the activity of the tested derivatives^[2].