Glycyl-L-proline
CAS No. : 704-15-4
(Synonyms: H-Gly-Pro-OH; Gly-Pro)
| Size | Price | Stock |
|---|---|---|
| 1g | $34 | In-stock |
| 5g | $115 | In-stock |
| 10g | $193 | In-stock |
| 25g | $386 | In-stock |
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| Cat. No. : | HY-W016887 |
| M.Wt: | 172.18 |
| Formula: | C7H12N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 1 mg/mL (ultrasonic;warming;heat to 60°C);H2O : 10 mg/mL (ultrasonic) |
Glycyl-L-proline (H-Gly-Pro-OH) is a dipeptide. Glycyl-L-proline can induce MCF-7 cells apoptosis. Glycyl-L-proline can enhance the inhibitory effect of the PRODH/POX knockout on collagen and DNA biosynthesis. Glycyl-L-proline can inhibit Gly-Sar and L-proline transport. Glycyl-L-proline can be used for the researches of cancer and metabolic disease, such as breast cancer[1][2][3].
In Vitro: Glycyl-L-proline (17,22 μg/ml; 24 h) does not significantly affect cell viability in MCF-7 and MCF-7shPRODH/POX (knocked-down PRODH/POX) cells[1].
Glycyl-L-proline (17,22 μg/ml; 24 h) induces apoptosis in MCF-7 cells[1].
Glycyl-L-proline (17,22 μg/ml; 24 h) decreases collagen biosynthesis and DNA biosynthesis in MCF-7shPRODH/POX[1].
Glycyl-L-proline (10-50000 μM; 10 mins) decreases intracellular Gly-Sar uptake in Caco-2 cells with an IC50 of 257 µM[2].
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