DPBQ
CAS No. : 7029-89-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $350 | In-stock |
| 10mg | $560 | In-stock |
| 25mg | $1100 | In-stock |
| 50mg | $1750 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-U00441 |
| M.Wt: | 362.38 |
| Formula: | C24H14N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 2.94 mg/mL (ultrasonic;warming;heat to 80°C) |
DPBQ activates p53 and triggers apoptosis in a polyploid-specific manner, but does not inhibit topoisomerase or bind DNA. DPBQ elicits expression and phosphorylation of p53 and this effect is specific to tetraploid cells[1]. IC50 & Target: p53[1] In Vitro: DPBQ elicits apoptosis and cell death and is selective for effects in 4N cells. DPBQ elicits expression and phosphorylation of p53 and this effect is specific to tetraploid cells. Knockdown of TP53 restores proliferation of tetraploid cells in the presence of DPBQ[1].
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