STING agonist-1
CAS No. : 702662-50-8
(Synonyms: G10)
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $120 | In-stock |
| 25mg | $240 | In-stock |
| 50mg | $380 | In-stock |
| 100mg | $570 | In-stock |
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| Cat. No. : | HY-19711 |
| M.Wt: | 430.88 |
| Formula: | C21H16ClFN2O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 75 mg/mL (ultrasonic) |
STING agonist-1 (G10) is human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM[1].
IC50 & Target: IC90: 24.57 μM (VEEV)[1]
In Vitro: G10 induces IFN/IRF3- but not NF-κB-dependent transcription in human fibroblasts[1].
G10 is an indirect activator of human STING-dependent phenotypes[1].
G10-mediated IRF3 activation and anti-Alphaviral activity occur independently of IPS-1/MAVS-dependent signaling[1].
STING is required for G10-mediated IRF3 activation, gene expression, and anti-Alphaviral activity[1].
G10 induces STING-dependent synthesis and secretion of bioactive interferon[1].
G10 induces innate antiviral mRNA expression in primary human cells[1].
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