SH-5
CAS No. : 701976-54-7
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|---|---|---|
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| Cat. No. : | HY-100702 |
| M.Wt: | 598.75 |
| Formula: | C29H59O10P |
| Purity: | >98 % |
| Solubility: |
SH-5 is a potent AKT inhibitor. SH-5 potentiates the apoptosis induced by tumor necrosis factor. SH-5 blocks NF-kB activation induced by TNF-a, lipopolysaccharide (HY-D1056), phorbol ester (HY-18739), and cigarette smoke[1].
In Vitro:SH-5 (5 µM; 4+24 h) increases the cytotoxicity with 1 nM TNF in H1299 cells[1].
SH-5 (5 µM; 4+0, 6, 12, 18, 24 h) potentiates the apoptosis induced by tumor necrosis factor (TNF) in H1299 cells[1].
SH-5 (1, 3, 5 µM) inhibits TNF (1 nM; 24 h)-induced COX-2 gene expression in a dose-dependent manner[1].
SH-5 (5 µM; 4+0, 6, 12, 18, 24 h) decreases the protein expression of 1 nM TNF-induced IAP-1, XIAP, Bcl-Xl, Bcl-2, TRAF1, Survivin, COX-2, Cyclin D1, MMP-9 in a time-dependent manner in KBM-5 cells[1].
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