T863
CAS No. : 701232-20-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $92 | In-stock |
| 10mg | $139 | In-stock |
| 25mg | $301 | In-stock |
| 50mg | $502 | In-stock |
| 100mg | $884 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-32219 |
| M.Wt: | 394.47 |
| Formula: | C22H26N4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
T863 is an orally active, selective and potent DGAT1 (acyl-CoA:diacylglycerol acyltransferase 1) inhibitor with an IC50 of 15 nM. T863 has no inhibitory activity against human MGAT3, human DGAT2, or human MGAT2. T863 interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells[1][2]. IC50 & Target:IC50: 15 nM (DGAT1)[2] In Vitro:T863 (for 3 days) enhanceS insulin-stimulated glucose uptake, suggesting a possible role for adipocytes to improve insulin sensitivity upon DGAT1 inhibition in differentiated 3T3-L1 adipocytes[1]. In Vivo:T863 (30 mg/kg; oral administration) causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity[1].
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