Methyl gerfelin
CAS No. : 700870-56-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $156 | In-stock |
| 10mg | $250 | In-stock |
| 25mg | $450 | In-stock |
| 50mg | $720 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-124824 |
| M.Wt: | 304.29 |
| Formula: | C16H16O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Methyl gerfelin inhibits osteoclast differentiation by binding 3 major cellular proteins: glyoxalase 1 (GLO1), sterol binding protein 2 (SCP2), and small glutamine-rich tetratricopeptide repeat containing protein A (SGTA). Methyl gerfelin is a potent GLO1 inhibitor related to the flavonoid class[1][2].
IC50 & Target:Glyoxalase 1 (GLO1), Sterol binding protein 2 (SCP2), Small glutamine-rich tetratricopeptide repeat containing protein A (SGTA)[1]
In Vitro:Methyl gerfelin (0-30 μM; 72 h) suppresses osteoclastogenesis with an IC50 value of 2.8 μM without affecting the survival and function of mature osteoclasts at the effective concentration[1].
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