NSC-60339
CAS No. : 70-09-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $370 | In-stock |
| 10mg | $550 | In-stock |
| 50mg | $1220 | In-stock |
| 100mg | $1650 | In-stock |
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| Cat. No. : | HY-119172 |
| M.Wt: | 486.95 |
| Formula: | C26H23ClN6O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic) |
NSC-60339, an efflux pump inhibitor and a substrate of AcrAB-TolC, is a polybasic terephthalic acid derivative studied as a potential cancer chemotherapeutic agent[1][2]. In Vitro: NSC 60339 has been correlated with the sensitivity, resistance, or cross-resistance of 7 tumor lines to phthalanilide treatment in vivo. The sensitive tumors (L1210, L1210/MTX, L1210/ara-C, and P815) rapidly takes up the drug and retained it primarily as lipid-bound drug for the 24-hr experimental period. The resistant tumor, L1210/NSC 60339, and 2 cross-resistant tumors, P388/VCR and P815/VLB, took up as much drug as the sensitive tumors did by 0.5 hr, but there was an efflux of lipid-bound drug from these resistant tumors by 24 hr[3].
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