Pelubiprofen
CAS No. : 69956-77-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $95 | In-stock |
| 25mg | $180 | In-stock |
| 50mg | $290 | In-stock |
| 100mg | $460 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12383 |
| M.Wt: | 258.31 |
| Formula: | C16H18O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Pelubiprofen is an orally active anti-inflammatory agent that inhibits COX enzyme activity (with IC50 values of 10.66 and 2.88 μM for COX-1 and COX-2, respectively). Pelubiprofen has significant anti-inflammatory and analgesic effects[1][2].
In Vitro:Pelubiprofen (0.01-60 μM, 24 h) inhibits COX in RAW 264.7 cells and suppresses LPS (HY-D1056)-induced PGE2 (IC50 is 0.13 μM)[1].
Pelubiprofen (15-60 μM, 24 h) inhibits the expression of iNOS and pro-inflammatory cytokines induced by LPS (HY-D1056) in RAW 264.7 cells[1].
Pelubiprofen (15-60 μM, 24 h) suppresses the activation of NF-κB induced by LPS (HY-D1056) in RAW 264.7 cells[1].
Pelubiprofen (15-60 μM, 24 h) inhibits IKK and TAK1 in RAW 264.7 cells induced by LPS (HY-D1056)[1].
In Vivo:Pelubiprofen (25-100 mg/kg, oral, single dose) inhibits the anti-inflammatory effect of NF-κB in the carrageenan-induced paw edema model[1].
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