Swertisin
CAS No. : 6991-10-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $80 | In-stock |
| 5mg | $320 | In-stock |
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| 50 mg | Get quote | |
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| Cat. No. : | HY-N2189 |
| M.Wt: | 446.40 |
| Formula: | C22H22O10 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Swertisin is an oral adenosine A1 receptor antagonist and an SGLT2 inhibitor. Swertisin has anti-diabetic, antioxidant properties, inhibits HBV, and improves cognitive and memory impairments in mice[1][2][3].
In Vitro:Swertisin (7.5 μg/mL, 0-12 h) inhibits glucose uptake in HEK293 cells and reduces the expression of SGLT2[2].
Swertisin (0.2-5 μM, 6-12 days) suppresses levels of HBsAg, HBeAg and HBV DNA in HepG2.2.15 and HBV-infected HepG2-NTPC cells[3].
In Vivo:Swertisin (30 mg/kg, orally, single dose) helps improve symptoms of schizophrenia in mice, including sensory motor gating disruptions and cognitive impairments[1].
Swertisin (2.5 mg/kg, intraperitoneally, once daily, days) reduces the expression of SGLT2 in mouse kidney tissue and can quickly lower blood sugar[2].
Swertisin (0-10 mg/kg, intraperitoneally, every other day, 20 days) significantly inhibits HBV replication in a HBV transgenic mouse model[3].
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