Darinaparsin
CAS No. : 69819-86-9
(Synonyms: ZIO-101; S-Dimethylarsino-glutathione)
| Size | Price | Stock |
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| 10mg | $284 | In-stock |
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| Cat. No. : | HY-14943 |
| M.Wt: | 411.31 |
| Formula: | C12H22AsN3O6S |
| Purity: | >98 % |
| Solubility: | H2O : 62.5 mg/mL (ultrasonic) |
Darinaparsin (ZIO-101), an organic arsenical, is a mitochondrial-targeted agent. Darinaparsin induces apoptosis in ancer cells, and has anticancer effects[1]. In Vitro:Darinaparsin is cytotoxic to prostate cancer cell lines as well as fresh prostate cancer cells at low micromolar concentrations, and importantly inhibits the termed tumor-initiating cells (TIC) subpopulations[1]. In Vivo:Darinaparsin inhibits growth of the castrate-resistant Du145 prostate tumor propagated as xenograft in mice and inhibits the tumor-initiating potential of prostate cancer cells[1].
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