Didanosine
CAS No. : 69655-05-6
(Synonyms: 2',3'-Dideoxyinosine; ddI)
| Size | Price | Stock |
|---|---|---|
| 5g | $175 | In-stock |
| 10g | $250 | In-stock |
| 25g | $400 | In-stock |
| 100g | $825 | Get quote |
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| Cat. No. : | HY-B0249 |
| M.Wt: | 236.23 |
| Formula: | C10H12N4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Didanosine (2',3'-Dideoxyinosine; ddI) is a a potent and orally active dideoxynucleoside analogue, and also is a potent nucleoside reverse transcriptase inhibitor. Didanosine shows antiretroviral activity for HIV[1][2][3].
In Vitro:Didanosine is converted by cellular enzymes to the active antiviral metabolite dideoxyadenosine triphosphate (dd-ATP) and the intracellular half life of dd-ATP varies from 8-24 hours[1].
Didanosine shows antiretroviral activity with IC50 value of 0.24-0.6 mg/L for HIV infection[3].
Didanosine (5, 10, 50, 100 ug/ml; 24, 48 h) shows no significant inhibition of cell proliferation in IEC-6 cells[2].
In Vivo:Didanosine (100, 150 mg/kg; p.o.; daily for 7 days) decreases the length of duodenal and in jejunal villus in mouse[2].
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