(E/Z)-GO289
CAS No. : 694522-87-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $250 | In-stock |
| 25mg | $430 | In-stock |
| 50mg | $650 | In-stock |
| 100mg | $950 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-115519 |
| M.Wt: | 419.30 |
| Formula: | C17H15BrN4O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C) |
(E/Z)-GO289 is a potent and selective casein kinase 2 (CK2) inhibitor (IC50=7 nM). (E/Z)-GO289 strongly lengthens circadian period. (E/Z)-GO289 exhibits cell type–dependent inhibition of cancer cell growth that correlated with cellular clock function[1].
In Vitro: (E/Z)-GO289 is a potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.(E/Z)-GO289 shows an IC50 of 13 μM for PIM2 and is >1000 times higher than that for CK2[1].
(E/Z)-GO289 (3-9 μM; 2 days) strongly inhibits Caki-2, A498, and 769-P cells[1].
(E/Z)-GO289 enables manipulation of clock protein phosphorylation and cancer cell growth[1].
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